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For gut healing applications, some practitioners recommend dosing around meals in specific patterns

One potential toxicity mechanism of PPIs as suggested from this systematic PPI-specific gene expression analysis is that PPIs are enriched in acidic organelles where they are activated and inhibit V-ATPases and acid hydrolases, and consequently block the pathways of antigen presentation, the synthesis and secretion of cytokines, and complement component proteins and coagulation factors.[237] Related Articles Hypochlorhydria (Low Stomach Acid) Gastroesophageal Reflux Disease (GERD) Intestinal Permeability/Leaky Gut Irritable Bowel Syndrome (IBS) Small Intestinal Bacterial Overgrowth The Neuroendocrine System of the Gut and the Brain-Gut Axis References 189