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2c and Supplementary Table 8), 105156 weeks ( n = 3, one trial each for liraglutide 31 , orlistat 32 and semaglutide 17 reporting a placebo-subtracted TBWL of 4.2%, 3.0% and 8.7%, respectively) and more than 156 weeks (one trial with orlistat 32 reporting a 3% TBWL compared to placebo and one subgroup analysis of a trial with tirzepatide 33 reporting 19.3% TBWL)

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This phase-specific design ensures sequential regulation across the inflammatory, proliferative, and remodeling stages of healing