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At 6 grams, the effect becomes meaningful for cardiovascular or performance outcomes in most people, and this article covers standard doses, therapeutic ranges, timing, and how to adjust based on your goal

Phase 3: Maintenance (Weeks 912) Dose: 1.64.8 mg 23 weekly Pulsed administration keeps the repair signal present without turning the protocol into constant stimulation

But the trajectory matters

Indeed, Kang reported that human volunteers who ingested supratherapeutic doses of APAP (80 mg/kg) excreted dramatically lower amounts of APAP oxidative (CYP450) metabolites in urine when treated with fomepizole ( Figure 21 )