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Alarcn-Ars D, Recasens A, Galofr M, Carballo-Carbajal I, Zacchi N, Ruiz-Bronchal E, Pavia-Collado R, Chica R, Ferrs-Coy A, Santos M et al (2018) Selective -Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinsons Disease

Protein identification of MCMs and SP@M Then, SP, MCMs, and SP@M protein were subjected to SDSPAGE gel electrophoresis for separation and following the electroblotting process for further WB assay

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So the tetrasubstituted core is three stability modifications plus one potency modification, bundled together and usually described as though all four were the same kind of fix