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Sci Rep (2022) 12(1):7290

Study 1 The safety, efficacy, and PK of ADYNOVATE were evaluated in a multicenter, open-label, prospective, non-randomized, two-arm clinical trial (Study 261201, NCT01736475) that compared the efficacy of a twice weekly prophylactic treatment regimen to on-demand treatment and determined hemostatic efficacy in the treatment of bleeding episodes

Glucagon receptor activation in the liver and brown adipose tissue increases basal metabolic rate by stimulating thermogenesis, the process by which the body generates heat by burning calories without mechanical work