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The IRS-1 G972R Polymorphism and Type 2 Diabetes: A Paradigm for the Difficult Ascertainment of the Contribution to Disease Susceptibility of Low Frequency-Low Risk Variants. Nesti, Lorenzo, et al

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These coepidemic conditions result in a huge patient population that can be reached, with around 85-90% of the type 2 diabetes cases being attributed to excess body weight/central adiposity

Results of a previous in vitro study indicated that arbutin-loaded liposomes had a slower drug flux and absorption rate along with higher and longer skin deposition in comparison to arbutin solution