The choice of liraglutide was substantiated by its favorable pharmacokinetic profile in patients with impaired kidney function and therefore by its increasing clinical use in this population 12
DECLARATIONS Authors contributions Controlled the study design and preparation of the article: Ciancimino G, Pecorella F, Viscardi SM, La Mantia C, Caserta A, Pennisi G, Petta S Participated in planning and drafting the article: Ciancimino G, Pecorella F, Viscardi SM, La Mantia C, Caserta A, Pennisi G, Petta S Approved the final draft of the article: Ciancimino G, Pecorella F, Viscardi SM, La Mantia C, Caserta A, Pennisi G, Petta S Availability of data and materials Not applicable
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
The glucagon receptor component does not appear to cause significant glucose-raising effects in the context of GLP-1 co-activation, suggesting that the three receptor pathways balance each other in important ways