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Goth, a Hungarian biochemist, first described Hungarian acatalasemia in 1992 after studying the disease in two Hungarian sisters

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While some patients - around 40% - report mild to moderate gastrointestinal side effects, only about 5% discontinue treatment due to these issues

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found that IL-17 increased reactive oxygen species (ROS) production and activated oxidative stress, activating endothelial contractile machinery

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