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Adding Cagrilintide Cagrilintide is a long-acting amylin analog shown in trials to significantly enhance weight loss when combined with semaglutideup to ~20 % body weight loss over 68 weeks versus ~1115 % with single-agent therapy

It is found in most body cells, with the highest concentration in the liver

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In this latest trial, however, the researchers said they found no increased risk of acute kidney injury linked to semaglutide treatment