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Subsequent increases in the permeability of the intestinal barrier in CKD patients promote the translocation of bacterial products of intestinal origin, such as LPS, uremic toxins, and cytokines, into the systemic circulation, resulting in local and systemic inflammation, as well as oxidative stress associated with CKD (Krukowski et al., 2023

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Glucagon Receptor Activation: Increases energy expenditure and promotes fat loss through enhanced metabolic activity

Ensuring adequate protein intake supports muscle maintenance, which is crucial for maintaining metabolic heat production during weight loss