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Emerging evidence demonstrates that tumor cells possess the ability to sense and interpret these signals through mechanosensors and mechanotransducers, including mechanosensitive ion channels (e.g., ion channels that belong to the transient receptor potential (TRP) family), ion transporters, focal adhesions, cytoskeletal elements, nuclear proteins, and transcription factors

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Moreover, the topical administration of EGCG in mice with monobenzone-induced vitiligo reduced serum levels of the pro-inflammatory cytokines TNF-, IFN-, and IL-6, as well as the perilesional CD8+ T cells accumulation [56]