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If the dietary intake or absorption of L-Lysine cannot keep up with this massive metabolic demand, the patient enters a state of localized amino acid depletion

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The potential mechanism is at least partly due to the histone deacetylase 3 suppression-mediated miR-200a/Kelch-like ECH-associating protein 1 (Keap1)/Nrf2 signaling pathway and downstream targeting junction protein expression in db/db mice [106]