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The evolving story of incretins (GIP and GLP -1) in metabolic and cardiovascular disease: A pathophysiological update

Theyre involved in cell movement, wound repair, skin barrier function, hormone production, energy use the list goes on

J.GallwitzB.SalmenS.GoetzeO.HolstJ.SchmidtW.et al (2003)

Upon hypoxia, HIF-1 is stabilized and translocates to the nucleus, where it dimerizes with HIF-1, binds to target genes, and activates gene transcription