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All doses of tirzepatide and semaglutide were superior to placebo in achieving at least a 10% body weight reduction, with tirzepatide 15 mg (risk ratio = 10.51 [95% CI 7.55, 14.64]) and tirzepatide 10 mg (risk ratio = 8.84 [95% CI 6.35, 12.32]) being the most efficacious treatments (ESM Table 13)

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On one hand, the stability of carnosine is compromised due to its rapid hydrolysis by carnosinase, as well as the influence of environmental factors such as temperature, pH, and metal ions 34,35

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