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The cytokine expression in peripheral blood mononuclear cells after trickle infections was polarized more towards a Th2 response with a gradual increase in the Th1 profile in the chronic disease stage

Pulmonary fibrosis is characterized by the accumulation of myofibroblasts, the activated form of fibroblasts, which are responsible for the pathogenic synthesis of collagen and the deposition of the extracellular matrix in the alveolar structures (Mostafa et al., 2022)

Harmful substances and microorganisms in the intestinal tract could enter the bloodstream, triggering an immune response that may lead to systemic inflammation

GDH is allosterically regulated by activators like ADP and leucine, or by inhibitors like ATP, GTP and palmitoyl-CoA [71-73]