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This metabolic shift is hypothesized to enhance mitochondrial function, reduce oxidative stress, and modulate neurotransmitter balance (Lim et al., 2022)

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34 Angarita et al 15 found that pretreatment with a clinically relevant (antidiabetic) dose of exenatide (5 g, 0.02 mL) did not alter the cocaine-related behaviors or subjective effects such as euphoria and wanting cocaine in people with cocaine use disorder compared to placebo (saline 0.02 mL)