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According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, obese patients receiving incretin-based therapies for weight loss should be monitored for the development of pancreatitis

Daily losses through urine, faeces, and desquamated cells amount to approximately 0.1% of body stores, meaning it can take 35 years for deficiency to develop in someone with normal stores who stops absorbing B12

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