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The landmark Diabetes Prevention Program (DPP) trial found that metformin participants lost an average of 2.1kg (about 2% of body weight) over 2.8 years

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Last reviewed: June 15, 2026 Last updated: June 15, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations