sglt2 vs glp 1 vs dpp4

sglt2 vs glp 1 vs dpp4 Effect of dual inhibition of and on tacrolimus‐induced diabetes mellitus and nephrotoxicity in a rat model - Ko - 2022 - American Journal of Transplantation Diabetes Management in Patients with

Name: sglt2 vs glp 1 vs dpp4 Effect of dual inhibition of and on tacrolimus‐induced diabetes mellitus and nephrotoxicity in a rat model - Ko - 2022 - American Journal of Transplantation Diabetes Management in Patients with
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Methods The current study involves the fusion of a native or mutant GLP-1 (30 residues) with an HSA-binding DARPin (123 residues) via a rigid helical linker (15 residues) to create fusion proteins (168 residues) resistant to DPP-IV and, or trypsin with extended half-lives using structural modeling, which are subsequently characterized using MD simulation and molecular docking analyses