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84 Implications and Future Directions Given the positive results of the dietary supplements in reducing depressive symptoms, we suggest that people with depression consult with a specialist before selecting the type of supplementation

resM, being a supplement with common botanical ingredients, is unlikely to cause significant side effects beyond mild digestive discomfort

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However, previous studies have examined the ability of GLP-1 receptor agonists to decrease opioid self-administration under a PR schedule of reinforcement following reinstatement, and these studies examining animal subjects under a PR schedule of reinforcement following extinction training and subsequent reinstatement have found that GLP-1 receptor agonists consistently decrease self-administration [30-32,35-38]