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Oba receptory GLP-1R i GIPR s sprzone z biakiem G, wic zwizanie agonisty przekada si na wzrost wewntrzkomrkowego cAMP i uruchomienie szlakw zalenych od kinazy PKA

PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024