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These results are consistent with the major features of hind-limb suspension-related phenotypes of skeletal muscles as an index of anti-gravity muscle atrophy 66 , thus assuring that the experimental design including the mouse age and muscle-disuse period (in vivo assay time-point) were appropriate to the conclusion that 3-days LASSS oral-administration prevents tyrosine-residue nitration of extracellular HGF (Y198) during 5-days muscle disuse

In vitro studies demonstrated that AOD-9604 can directly stimulate lipolysis in isolated human adipocytes, though the potency was lower than native GH or synthetic lipolytic agents like epinephrine or isoproterenol

no adverse events or symptoms were reported from the subjects in both groups (placebo and L-carnitine)