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Description

Tirzepatide's mechanism stays within incretin pathways, which is why its weight-loss ceiling sits below retatrutide's in head-to-head modelling

J Neurosci 2000

However, reaction with the enzyme allene oxide cyclase (3) yields only 12oxo9 S ,13 S -phytodienoic acid (the cis -(+)-enantiomer - 12oxoPDA), which is the primary isomer of biological relevance