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GLP-2R Expression in the Gut The human GLP-2 receptor is localized to chromosome 17p13.3 and encodes a 550 amino acid G protein-coupled receptor, processed to become a 486 amino acid receptor (Munroe et al., 1999)

Steady-state plasma concentration is reached after 45 weeks of consistent dosing

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Mechanistically, PT141: Acts as an agonist at melanocortin4 (MC4R) and melanocortin1 (MC1R) receptors, with primary relevance to sexual behavior and energy balance through MC4R in the CNS and additional roles in pigmentation, inflammation, pain, and infection via MC1R