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Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial

These mast cell mediators provoke potent inflammatory responses that can include urticaria (AKA hives-skin rash and swelling), angioedema (swelling beneath the skin surface), bronchoconstriction (airway constriction), diarrhea, vomiting, hypotension (low blood pressure), cardiovascular collapse, and death, all within a matter of minutes

The mechanism of action favours its potential as a skin lightening agent

However, if you are using multiple active ingredients, it is best to introduce them gradually into your routine