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Crucially, some studies provided direct barrier or permeability-related readouts: WTD reported enhanced barrier function accompanying TNF-/IL-6 reduction ( 5.3.3 Summary box Conclusion: Intestinal barrier - systemic inflammation axis is common in a variety of interventions and models, so it is the most suitable convergence endpoint/mechanism landing point for different metabolic modules to achieve remote immune regulation

For levothyroxine , patients should maintain consistent timing of administration (typically on an empty stomach) and thyroid function should be monitored after starting or stopping tirzepatide, as absorption changes may necessitate dose adjustments