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Demand for obesity therapeutics keeps expanding as lower-cost, easier-to-administer oral pill versions of the current injectable GLP-1s are introduced to the market in 2026, and the field now spans an entrenched leader, a deep-value incumbent, and a clinical-stage challenger with multiple near-term catalysts

Patients with specific genetic patterns in these regions may experience more or less appetite suppression from semaglutide, affecting how well it counteracts steroid-induced hunger

The likely arrival of Novo Nordisks high-dose semaglutide pill in late 2025 may also take up some of the consumer base for orforglipron

Frequently Asked Questions Is weight gain on semaglutide a sign the medication isn't working