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Drug and Challenge Dose Selection The selection of an incretin mimetic dose for evaluation in neurotrophic, neuroprotective, and inflammatory studies across SH-SY5Y, HMC3, and IMG cells was based on pilot doseresponse studies that were focused on identifying the threshold concentration to provide the biological action of interest, and this dose was then used across single, dual, and triple receptor agonists to allow their side-by-side comparison at an equimolar concentration

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