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GLP-1 receptor agonists such as semaglutide established that pharmacologic activation of gut hormone pathways could produce double-digit percentage weight loss in many patients

Its FDA-approved to treat acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women, but some healthcare providers may consider it for other libido concerns

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This mechanism has been in clinical use for over 60 years, making it one of the longest-established appetite suppressants in modern medicine