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The structure showed the peptide clasped between the two domains and a sharp kink forming in the middle of transmembrane helix 6, which swings the receptors intracellular half outward to make room for the G protein

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2.1 Criteria for identifying underexplored peptide systems To operationalize this definition, peptidereceptor systems considered underexplored in this review meet several criteria

Enzyme induction, receptor cross-talk, altered clearance rates, and unexpected feedback loop modifications are all possibilities that theoretical analysis cannot reliably predict