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Sep 23 2020 de Alencar et al., Clinical Infectious Diseases, doi:10.1093/cid/ciaa1443 Double-blind, Randomized, Placebo-controlled Trial With N-acetylcysteine for Treatment of Severe Acute Respiratory Syndrome Caused by Coronavirus Disease 2019 (COVID-19) 3% higher mortality (p=0.94) , 16% higher ventilation (p=0.64) , 9% lower ICU admission (p=0.65) , and 10% longer hospitalization (p=0.87)

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Greater change often follows dose increases from 0.5 mg to 1 mg and eventually 2 mg, along with consistent use and lifestyle changes