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Effects of medical comorbidity on male infertility and comorbidity treatment on spermatogenesis

For treatment of T2D amongst patients without pre-existing cardiovascular or renal complications who are not adequately controlled on metformin (with or without sulfonylurea), in order to reduce HbA1c levels, international [13] and Danish [14] guidelines recommend intensifying with anti-diabetic treatment options such as dipeptidyl peptidase-4 inhibitors (DPP4is), sodiumglucose cotransporter 2 inhibitors (SGLT-2is) and glucagon-like peptide 1 receptor agonists (GLP-1RAs)

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