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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

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Furthermore, subjects in the multiple-dose trial fasted for 2 h after each dosing of oral semaglutide, while the more recent dosing guidance used in the phase III trials requests subjects to fast for at least 30 min after dosing

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