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Four weeks of moderate-intensity treadmill exercise significantly inhibited the activation of the STING signaling pathway in the damaged cortex of traumatic brain injury mice, downregulated the expression of TFR1, FTH, and ACSL4, upregulated FPN, System Xc , GPX4, and GSH expression, and reduced levels of 4-HNE, MDA, and Fe 2+

MTHFR, or the methylenetetrahydrofolate reductase is the key regulatory enzyme in folate and homocysteine metabolism