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NAD+ levels decline approximately 50% between ages 40 and 60 (Massudi et al., 2012), driving interest in direct supplementation to restore youthful concentrations

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To further confirm this result, we treated tendon fibroblasts with BPC 157 at different concentrations (0, 0.1, 0.25 and 0.5 g/mL) for 24 h and the expression of growth hormone receptor was found to increase in a dose-dependent manner (Figure 1A,C)