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Juei-Tang Cheng Joshua Reed, Stephen C Bain, Venkateswarlu Kanamarlapudi Institute of Life Science, Medical School, Swansea University, Swansea, SA2 8PP, UK Correspondence: Venkateswarlu Kanamarlapudi, Institute of Life Science, Medical School, Swansea University, Swansea, SA2 8PP, UK, Tel +44 1792 295012, Fax +44 1792 602148, Email [email protected] Abstract: In healthy humans, the complex biochemical interplay between organs maintains metabolic homeostasis and pathological alterations in this process result in impaired metabolic homeostasis, causing metabolic diseases such as diabetes and obesity, which are major global healthcare burdens

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