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In fact, the American Optometric Association released an alert in August 2024 advising consumers to consult with a certified doctor before using any eye drops that claim to change your eye color

2000 Jan-Feb;21(1):53-7

Prednisolone was associated with a non-significant decrease in 28-day mortality, with no change in mortality at 90 days or 1 year in a well-conducted study [26]