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Val3-Asp4 interact with similar residues at the base of the binding cavity to those observed for residues 2 and 3 of the other peptides, however, with the exception of Y148 1.43 , these were very transient (Supplementary Table 3)

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The approved landscape is already crowded (10+ approved molecules globally), yet the pipeline is even more active, with 566+ active Phase 3 trials and 749 total drugs in development