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Additional anti-diabetic medication and rescue medication was permitted in each of the included studies, with the exception of PIONEER 6

Side effects like mild nausea often improve after weeks two through four as your GI tract adapts, allowing you to enjoy meals more fully while still eating smaller portions

HSL-null mice displayed lower serum NEFA and TAG levels and reduced hepatic TAG storage, indicating that HSL-independent lipolysis was inadequate to maintain FA output from adipose tissue at levels that could meet normal demands for energy substrates and VLDL synthesis (45, 132)