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The FDA label for Zepbound does not list hormonal interaction as a mechanism

After the initial reduction in appetite, the food intake of the experimental groups increased to the same amount as the rats in the control group, however, both the high dose and low dose groups were seen to have maintained a lower level of body weight despite the increase in calories

Injection pens need only be refrigerated prior to their first use (check the guidance available for each medication, as room temperature storage guidelines vary)

However, those with pre-existing kidney disease, multiple risk factors, or experiencing significant gastrointestinal side effects should undergo more frequent assessment as clinically indicated