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When levels drop below the lower quartile of normal range, even if technically 'within normal limits' on a lab report, cardiac rhythm becomes more susceptible to ectopic beats and premature ventricular contractions (PVCs)

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27 Evidence From Clinical Trials The clinical evidence supporting the use of GLP-1RAs in HF has primarily emerged from cardiovascular outcome trials (CVOTs) in patients with T2D and dedicated HF trials ( Table 1 )