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As a result, in mice on HFD-induced NAFLD model, Cori treatment strikingly lowered total NAFLD activity score (NAS) in a dose-dependent manner (decreased by 1.75 in HCR-L group and 2.44 in HCR-H group, respectively), which is the sum of hepatic steatosis inflammation and ballooning scores, in a dose- dependent manner (Figure 1E)

Isatinimino-acridinedione core 46 Diaryl triazole analogs have been shown to induce dual COX-2/TNF- inhibitory activities in previous studies (122, 123)

Similar content being viewed by others Introduction The incidence of certain allergic, autoimmune and metabolic diseases has been increasing in recent decades and has reached almost epidemic dimensions