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Because comparator groups often differ in treatment indication, disease duration and comorbidity profiles, residual confounding remains a primary concern, necessitating caution in causal inference. In a research letter published in Diabetes, Obesity and Metabolism , researchers obtained data from adults in the TriNetX database from January 2006 to October 2024

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Reconstitution (if applicable) Some compounded GLP-1 medications arrive as lyophilized powder that requires reconstitution with bacteriostatic water