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Myotubes could be induced to hypertrophy by the PI3K/Akt pathway, which increases protein synthesis and blocks the up-regulation of MAFbx and MuRF1 that occurs during muscle atrophy [54, 59]

The 5-gram creatine dose is what clinical research supports for daily maintenance, he said, and pairing it with electrolytes is genuinely smart since creatine works by pulling water into muscle cells. So, while creatine is assisting in muscle growth and recovery, the electrolytes are working to offset its dehydrating effects and keep the body balanced

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