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Abstract 518: Erk5 S496 phosphorylation, but not Erk5 kinase or transcriptional activity, is responsible for promoting macrophage inflammation and mitochondrial dysfunction via upregulating novel site of Nrf2 K518 sumoylation

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Iron or folate may also be needed

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This conversion is essentially irreversible under normal conditions

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Moreover, they provide a direct mechanistic link between a primary calcium-handling disease and structural remodelling in the heart

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