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Tirzepatide can be effective for weight management in steroid-treated patients, though the metabolic environment created by corticosteroids, including insulin resistance, increased appetite, and altered fat distribution, may affect the magnitude of response

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Moreover, the effects on body weight and not energy expenditure may be independent of GLP1 receptors in the ventromedial hypothalamus, as knockdown of GLP1 receptors in the ventromedial hypothalamus was not sufficient to block the effect of exendin4 to suppress food intake and improve glucose metabolism (Burmeister et al., 2017)

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