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J Diabetes Investig (2016) 7:505

The FDA has only approved six weight loss drugs, including: Bupropion-naltrexone (Contrave) Liraglutide (Saxenda) Orlistat (Xenical, Alli) Phentermine-topiramate (Qsymia) Semaglutide (Wegovy) Setmelanotide (Imcivree) Currently, the choice of weight loss drugs remains very limited and is divided into two main categories: pancreatic lipase inhibitors and appetite suppressants that act on the central nervous system

Because subcutaneous tissue has fewer blood vessels than muscle, the drug is absorbed gradually, which helps reduce sharp peaks and gives a smoother, more sustained effect

With smaller doses, one could theoretically go longer before needing to pay for a refill, depending on the brand and specific dosage of the pen, says Dr