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These medications mimic natural gut hormones that signal fullness to the brain, helping patients break cycles of overeating

Inhibition of the production of these inflammatory cytokines by modulating the gut microbiota can alleviate muscle atrophy (99)

In addition, sitagliptin (30 mg/kg/day) and exenatide (3 g/kg/12 h) significantly inhibited advanced glycation end products-induced oxidative stress in aortic endothelials in high fat diet (HFD)/STZ diabetic rats by reducing endothelin-1 (ET-1) and inflammatory cytokine via RhoA/Rho-associated protein kinase (ROCK)/NF- B signaling pathways and AMPK activation [67]