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Natarajan et al., 2014

Cytochrome P450 3A4 Interaction The concomitant use of hydrocodone bitartrate and acetaminophen tablets with all Cytochrome P450 3A4 inhibitors may result in an increase in hydrocodone plasma concentrations, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression

Inspect the injection site to ensure it is clear of bruising, swelling, irritation or hardness

Moreover, in Vgat-IRES-cre obese mice, only a higher tesofensine dose could suppress optogenetically induced feeding, suggesting that, during obesity, LH GABAergic neurons seem to be hypersensitized