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For many years, the only real option for treating premature ejaculation was with selective serotonin reuptake inhibitors (SSRIs).13 These are essentially antidepressants that have performed well in studies looking at them as PE treatments

GHK-Cu: Gene Expression and Tissue Remodeling Tissue repair , collagen synthesis, and extracellular matrix remodeling Anti-inflammatory signaling through inhibition of TNF- and IL-6 expression [1] Copper ion delivery into cells, promoting antioxidant enzyme function and cellular respiration [2] 2

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For example, a 10% increase in lactic acid concentration in the intestines of rats following intestinal injection of metformin (Bailey et al., 1992)